![]() In one clinical trial focused on inhibiting heat shock protein, the researchers will investigate a drug called SHetA2. “It will also help build a strong foundation of career support and training for early-career investigators, so they will be well positioned to continue this important work into the future.” “This new SPORE grant will help our patients gain access to innovative clinical trials of treatment and prevention strategies that have the potential to improve clinical care for endometrial cancer,” said Dineo Khabele, MD, the Mitchell and Elaine Yanow Professor and head of the Department of Obstetrics & Gynecology at Washington University. The new grant also provides funding for resources supporting all of these research initiatives, including a biospecimen core a biostatistics and bioinformatics core a metabolomics core an administrative core and programs for innovative research and career development to recruit and mentor early-career investigators focused on understanding, treating and preventing endometrial cancer. And a third project will be focused on the possibility of early detection and prevention through weight-loss strategies, including use of GLP-1 agonists, which are relatively newly available weight-loss drugs. A second team will investigate inhibitors that target elements of more aggressive uterine cancer these inhibitors block a key protein called the receptor tyrosine kinase AXL. One project team will investigate an inhibitor of important molecules called heat shock proteins. The funding will support three major research projects, each of which includes an early-phase clinical trial. We also hope our studies will be able to shed light on the racial disparities we see in this type of cancer.” “As part of the new SPORE, we will be investigating three key areas for potential treatment and prevention strategies. “We have been interested in this cancer for 30 years, but we have made very little headway in improving treatments or preventing it,” Mutch said. Mutch treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. and Judith Gall Professor of Obstetrics & Gynecology at Washington University. “Endometrial cancer is the most common gynecologic cancer and unfortunately - for reasons we don’t yet understand - is on the rise,” said principal investigator and gynecologic oncologist David G. These locations provide an opportunity to better address endometrial cancer in patient populations that have been historically underrepresented in cancer research and clinical trials and are disproportionately affected by endometrial cancer, including Black, American Indian and Hispanic patients. The researchers dubbed the program the Route 66 Specialized Program of Research Excellence because of the three universities’ locations along historic Route 66, which crosses the Midwest and Southwest. The five-year grant will provide about $11.6 million to research programs at Washington University, the University of New Mexico and the University of Oklahoma Health Sciences Center. Louis a prestigious Specialized Programs of Research Excellence (SPORE) grant. To spur new strategies to prevent and treat endometrial cancer, the National Cancer Institute (NCI) of the National Institutes of Health (NIH) has awarded researchers at Washington University School of Medicine in St. The grant will support innovative research initiatives with the goal of improving treatment and prevention of endometrial cancer.Ĭases of endometrial cancer - a gynecologic cancer of the lining of the uterus - have increased in recent decades, as have deaths caused by the condition. Louis have received a prestigious Specialized Programs of Research Excellence (SPORE) grant in endometrial cancer from the National Cancer Institute. Led by principal investigator David Mutch, MD, researchers at Washington University School of Medicine in St. NCI SPORE grant aimed at improving prevention, treatment, reducing disparitiesīy Julia Evangelou Strait ![]() News Release $11.6 million grant supports innovative research in endometrial cancer
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